Eldepryl for Life Extension
Eldepryl is one of the commonest trade names given to Selegiline (Deprenyl) by manufacturers. Other names include Azilect, Zelapar and Emsam but all in all they contain the same active ingredient; selegiline. Selegiline is a monoamine oxidase MAO enzyme inhibitor and was first developed in the 1960s for use an anti-depressant. It however proved to be ineffective but several clinical trials later, it was found to be useful in managing the symptoms associated with Parkinson’s disease. Since gaining FDA approval in 1989, Selegiline has proven useful in the treatment of this condition. This however is not the only benefit it confers to those who take it; it is known to have life extension benefits to all who take it. It is an anti-aging pill which when taken daily prolongs life.
Life extending capabilities of Eldepryl have been shown in scientific studies involving rodents and dogs. Eldepryl works as a MAO inhibitor to stop the breakdown of a neurotransmitter found in the brain known as dopamine. When dopamine is broken down faster than normal as is the case in aging people, it results in several symptoms including rigid muscles, loss of coordination and many more due to the death of brain cells that rely on dopamine for full functioning. By inhibiting the breakdown of this much-needed brain chemical, the brain is retained in its optimally functional state which is necessary for life extension.
Other than this, Eldeopryl works in the brain to increase the activity of endogenous antioxidant enzymes like superoxide dismutase and catalase. These work to curb the effects of free radicals that could result in development of cancer and are also responsible for destruction of body cells as is common with aging. The aforementioned enzymes work to get rid of these radicals and so the body cells remain intact. With less cells dying and more being made in normal cell division, aging is slowed down hence extending life. In a 2006 study, it was found that Eldepryl activates Nrf2 which is a gene transcription factor responsible for the direct activation of antioxidant enzymes.
In order for Eldepryl to be effective in life extension, the doses need to be administered in small amounts at a time else the effects are negated. This is what is known as hormesis. In animal studies, doses of 0.25 and 0.5mg per kg in body weight were shown to be effective in prolonging life while when the doses were increased to 1mg per kg in body weight, death was seen to occur much faster. In humans, the recommended dose is 35mg in a person weighing 70kgs but doses as high as 140mg per day have been proven to be effective.